Cohort View shows bi-allelic loss at TP53 in adrenocortical tumor (ACT).

TP53 germline mutations (+ marks) co-occur with gross LOH (dark bars). There is no segment length restriction for showing gross LOH. These tumors all retain the mutant alleles of the TP53 germline mutations. For example, by clicking on the mutation in one tumor (SJACT062_D), the tooltip showed that the Arg337His mutant allele fraction is nearly 100% in tumor DNA due to LOH. Variant frequency is based on 40 samples characterized by WGS or WES.