IKZF1 haploinsufficiency in B-cell acute lymphoblastic leukemia (BALL).

In BALL, IKZF1 is subject to whole locus or intragenic deletions (blue bars, limited to focal events under 2 Mb), translocations (not shown), and coding mutations (ticks). The IKZF1 coding mutations (n=28) rarely co-occur with either type of deletions (n=69), supporting the observation of haploinsufficiency of the tumor suppressor function of IKZF1 established from the mouse model (Virely et al. 2010).