Diverse alterations in B-ALL targeting CREBBP RING domain.

(A) Expanded Cohort View of pediatric cancer alterations around the CREBBP RING domain (exons 19-21), in which B-ALL displays most of the alterations.

(B) Sample View of SJHYPO056_D with homozygous loss of exon 21 caused by a focal deletion (blue bar for copy change, joint lines for SV breakpoints) accompanied by copy neutral-neutral LOH (black bar).

(C) Sample View of PANSXG with SV breakpoint projecting loss of exon 20 (cyan-shaded region).